DRUGS REPURPOSING AGAINST SARS-COV2 AND THE NEW VARIANT B.1.1.7 (ALPHA STRAIN) TARGETING THE SPIKE PROTEIN: MOLECULAR DOCKING AND SIMULATION STUDIES

Drugs repurposing against SARS-CoV2 and the new variant B.1.1.7 (alpha strain) targeting the spike protein: molecular docking and simulation studies

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is responsible for the global COVID-19 pandemic and millions of deaths worldwide.In December 2020, a new alpha strain of SARS-CoV2 was identified in the United Kingdom.It was referred to as VUI 202012/01 (Alpha strain modelled under investigation, 2020, month 12, number 01).The interaction

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Estimation of Seams in Paraglider Wing

The aim of the article is to analyze the seams connecting the covering textiles in paraglider wing and estimate their physical strength.The most extreme flight parameters (the angle of attack and velocity) in the numerical model of the wing allow the determination of the mean pressure inside the contour and the maximal difference between the pressu

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Post-translational regulation of Oct4 transcriptional activity.

Oct4 is a key component of the molecular circuitry which regulates embryonic stem childrens backpacks cell proliferation and differentiation.It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA in multiple heterodimer and homodimer configurations.Very little is known about ho

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Implementation of a national rapid prenatal exome sequencing service in England: evaluation of service outcomes and factors associated with regional variation

IntroductionPrenatal exome sequencing (pES) can enhance genetic diagnosis of fetuses with structural Multi-Tools anomalies and has recently been introduced as a national service in England.We aimed to examine service outcomes such as diagnostic yield (definite final diagnosis), referral rate, and sources of referral, and explore variation in outcom

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